ChIP-seq Profiling Identifies Histone Deacetylase 2 Targeting Genes Involved in Immune and Inflammatory Regulation Induced by Calcitonin Gene-Related Peptide in Microglial Cells

Figure 3

The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of genes with differentially enriched HDAC2 in microglial cells treated with CGRP. GO annotation of upregulated genes (a) or downregulated genes (b) with HDAC2 enrichments of the CGRP treatment group versus the control. Bar plots show the top ten fold enrichment values of the significant enrichment terms involving biological process (BP), cellular component (CC), and molecular function (MF). (c) KEGG pathway analysis of genes with differentially enriched HDAC2 in microglial cells treated with CGRP. The bar plot shows the top ten fold enrichment values of the significant enrichment pathway. Analysis by DAVID and KOBAS online tools (http://www.geneontology.org and http://www.genome.jp/kegg).

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