Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL-17/MIP-1β, IL-12/VEGF, and IL-10/IP-10 Axis

Figure 3

Phenotype profile of innate and adaptive immunity components in SCA subgroups according to laboratorial and clinical records. The frequency of cell phenotypes (a), the expression of Toll-like receptors (b) by innate immunity cells along with the cell phenotypes (c), and the expression of adhesion molecules by adaptive immunity cells (d) were analyzed in SCA subgroups by flow cytometry. The SCA patients were categorized according to their laboratorial and clinical records, including reticulocyte counts, platelet levels, and death risk scores. The results are presented in box plots with median and interquartile range overlaid by scatter plots with individual values for cell phenotype or mean fluorescence intensity (MFI). The interquartile ranges (25th-75th) for results observed in HD were used as reference range (gray background). Significant differences () are highlighted by connecting lines and asterisks ().