Analysis of Killer Cell Immunoglobulin-Like Receptor Genes and Their HLA Ligands in Inflammatory Bowel Diseases
Table 2
KIR genotypes in normal individuals and IBD patients.
KIR genotype
KIR genes
Patient (%)
Control (%)
value
OR (95% CI)
Inhibitory KIR
Activating KIR
Pseudogene
2DL1
2DL2
2DL3
2DL4
2DL5
2DL5A
2DL5B
3DL1
3DL2
3DL3
2DS1
2DS2
2DS3
2DS4 F
2DS4 V
2DS5
3DS1
2DP1
3DP1-1
3DP1-2
Ulcerative colitis vs. control
1
+
+
+
+
+
+
+
+
+
+
+
+
−
−
+
+
+
+
+
+
3 (3%)
8 (3%)
0.97
1.0 (0.2-3.9)
2
+
−
+
+
+
+
−
+
+
+
+
−
−
−
+
+
+
+
−
+
8 (8%)
23 (9.2%)
0.95
0.4 (0.4-2.2)
3
+
+
+
+
+
+
+
−
+
+
+
+
+
−
+
+
+
−
+
2 (2%)
7 (2.6%)
0.76
0.8 (0.2-3.8)
Crohn’s disease vs. control
1
+
+
+
+
+
+
+
+
+
+
+
+
−
−
+
+
+
+
+
+
3 (3.6%)
8 (3%)
0.75
1.2 (0.3-4.8)
2
+
+
+
+
+
+
+
+
+
+
+
+
+
−
+
+
+
+
−
+
2 (2.4%)
14 (5.4%)
0.31
0.46 (0.1-2.1)
3
+
−
+
+
+
+
−
+
+
+
+
−
−
−
+
+
+
+
−
+
5 (6%)
23 (9.2%)
0.48
0.69 (0.2-1.9)
4
+
+
+
+
+
+
+
−
+
+
+
+
+
−
−
+
+
+
−
+
4 (4.8%)
7 (2.6%)
0.30
1.9 (0.5-6.7)
5
+
−
+
+
+
+
−
+
+
+
+
−
+
−
+
−
+
+
−
+
5 (6%)
2 (0.7%)
0.01
8.7 (1.7-45.8)
6
+
+
+
+
+
+
+
+
+
+
+
+
+
−
+
−
−
+
−
+
9 (10.8%)
1 (0.4%)
0.001
33.2 (4.1-266.3)
A value less than 0.05 was statistically significant. Genotype frequency less than 2% is not included. KIR: killer cell immunoglobulin-like receptor; CD: Crohn’s disease; UC: ulcerative colitis.
