Research Article
Analysis of Killer Cell Immunoglobulin-Like Receptor Genes and Their HLA Ligands in Inflammatory Bowel Diseases
Table 3
Human leukocyte antigen (HLA) genotypes in normal individuals and IBD patients.
| | HLA genotype | HLA gene/allele | Patients (%) | Control (%) | value | OR (95% CI) | | HLA-C1Asn80 | HLA-C2Lys80 | HLA-B-Bw4Thr | HLA-B-Bw4Ile80 | HLA-A-Bw4 |
| | Ulcerative colitis vs. control | | 1 | + | + | − | + | + | 3 (3%) | 22 (8%) | 0.09 | 0.35 (0.1-1.2) | | 2 | + | + | − | + | − | 23 (23%) | 40 (14.6%) | 0.056 | 1.74 (0.9-3.1) | | 3 | + | − | − | + | − | 10 (10%) | 31 (11.3%) | 0.72 | 0.87 (0.4-1.8) | | 4 | + | + | − | − | − | 14 (14%) | 32 (11.7%) | 0.55 | 1.23 (0.6-2.4) | | 5 | − | + | − | − | − | 10 (10%) | 24 (8.8%) | 0.71 | 1.16 (0.5-2.5) | | Crohn’s disease vs. control | | 1 | + | + | − | + | + | 4 (4.8%) | 22 (8%) | 0.33 | 0.58 (0.2-1.7) | | 2 | + | + | − | − | + | 5 (6%) | 19 (6.9%) | 0.77 | 0.86 (0.3-2.4) | | 3 | − | + | − | − | + | 5 (6%) | 4 (1.5%) | 0.03 | 4.33 (1.1-16.5) | | 4 | + | + | − | + | − | 15 (18.1%) | 40 (14.6%) | 0.44 | 1.29 (0.7-2.5) | | 5 | + | − | − | + | − | 10 (12%) | 31 (11.3%) | 0.85 | 1.07 (0.5-2.3) | | 6 | + | + | − | − | − | 5 (6%) | 32 (11.7%) | 0.14 | 0.48 (0.2-1.3) | | 7 | − | + | − | − | − | 11 (13.3%) | 24 (8.8%) | 0.23 | 1.59 (0.7-3.4) |
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A value less than 0.05 was statistically significant. Genotype frequency less than 2% is not included. |
