Deciphering Antitumor Mechanism of Pien Tze Huang in Mice of Hepatocellular Carcinoma Based on Proteomics

Figure 4

The key proteins and pathways of the molecule network involved in PZH and Sora treatment. (a) The molecular network based on the inflammation-related pathways. (b) The molecular network based on the cell cycle-related pathways. (c) The molecular network based on the cancer growth-related pathways. (d) PZH regulated more proteins enriched in IL-6, TNFR1/2, and NF-κB pathways than Sora. (e) PZH regulated more proteins in G2/M phase, whereas Sora regulated more proteins in G1/S phase. (f) Sora regulated more proteins related to the activity of kinases enriched in p53 and FAK pathways. Pink cycle represented PZH group, blue cycle indicated Sora group, and gray cycle indicated both PZH group and Sora group.

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