Research Article

Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson’s Disease

Figure 3

CB receptor is associated with TRPV1-activated neuroprotection in the striatum of MPTP-treated mice in vivo. The striatal tissues obtained from the same animals as those used in Figure 1 were immunostained with TH antibody for dopamine fibers. CON: PBS as control; C: capsaicin; M: MPTP; MC: MPTP and capsaicin; MCA2: MPTP, capsaicin, and AM251; MCA6: MPTP, capsaicin, and AM630. (a) Photomicrographs of TH+ fibers in the striatum. These data are representative of five to six animals per group. (b) The optical density of TH+ fibers in the striatum. Bars represent the of five to six animals per group. , significantly different from control. &, significantly different from MPTP. #, significantly different from MPTP and CAP (one-way ANOVA with the Neuman-Keuls post hoc test). Scale bars: 500 μm.