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Research type | Targets | Main findings |
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Genetic | ApoE-/-/gal-3-/- mice [52] | Atherosclerosis plaques were significantly smaller. |
ApoE-/-/gal-3-/- mice [53] | Aortic atherosclerosis plaques decreased and vascular adventitia inflammation reduced. |
Gal-3 knockout mice [54] | Lymphocyte amounts and macrophage infiltration decreased significantly. |
Gal-3-deficient macrophages [55] | Phagocytosis of erythrocytes reduced. |
|
Epidemiological | Heart failure patients [76] | Gal-3 level was significantly associated with the prognosis and mortality. |
Coronary heart disease patients [82] | Gal-3 level increased significantly in the unstable angina group. |
Myocardial infarction patients [86] | Gal-3 was regarded as an independent risk factor for reinfarction. |
Carotid atherosclerosis patients [29] | Gal-3 level was positively associated with carotid intima-media thickness and the prevalence of carotid atherosclerosis. |
Heart failure patients [79] | The sensitivity and specificity of Gal-3 for heart failure diagnosis were 94.3% and 65.1%, respectively. |
Patients with coronary artery disease [68] | Gal-3 was a significant and independent predictor. |
Patients with myocardial infarction [85] | Elevated Gal-3 was associated with mortality and heart failure. |
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