Inflammation Is Associated with Worse Outcome in the Whole Cohort but with Better Outcome in Triple-Negative Subtype of Breast Cancer Patients

Figure 1

Association between inflammatory pathway score and the clinical factors in breast cancer. (a) Disease-specific (DSS), disease-free (DFS), and overall survival (OS) of inflammatory score high (red line) and low (blue line) in whole METABRIC breast cancer cohort. Log-rank test was used to compare the groups with Kaplan-Meier survival curves. (b) Boxplots of the inflammatory scores by AJCC cancer stage, Nottingham pathological grade, and age at diagnosis (<40 yo, 40-70 yo, and <70 yo) in both METABRIC and TCGA cohorts. (c) Gene expression levels of SphK1, SphK2, and S1P receptor 1 by high vs. low inflammatory score. (d) Boxplots of the inflammatory scores by subtype and PAM50 classifications. Tukey-type boxplots show median and interquartile level values, and the ANOVA test is used to calculate values.

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