Inflammation Is Associated with Worse Outcome in the Whole Cohort but with Better Outcome in Triple-Negative Subtype of Breast Cancer Patients

Figure 4

Composition of tumor infiltrating immune cells and immune function scores by high or low inflammatory scores in METABRIC and TCGA cohorts. (a) anticancerous immune cells including CD8 T cells, CD4 memory T cells, M1 macrophages, and dendritic cells (DC); (b) procancerous immune cells including regulatory T cells, Type 2 helper T cells (Th2), and M2 macrophages; and (c) B cells and plasma cells in the TCGA and METABRIC cohorts. Comparison of high vs. low inflammatory scores in (d) cytolytic activity score (CYT). (e) Leukocyte fraction, tumor infiltrating lymphocyte (TIL) regional fraction, lymphocyte infiltration, Interferon-gamma (IFN-γ) response, T cell receptor (TCR) Shannon, TCR Richness, B cell receptor (BCR) Shannon, BCR Richness, and transforming growth factor-beta (TGF-β) response. Inflammation score in each cohort were divided into low and high groups by the median value. Tukey-type boxplots show median and interquartile level values, and the ANOVA test is used to calculate values.

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