The Scribble Complex PDZ Proteins in Immune Cell Polarities

Table 2

hScrib and hDlg1 interacting proteins in immune cells. Interactions of hScrib and hDlg1 in specific immune cells and functional outcome of each interaction are shown.

PDZ protein	Immune cell	Interacting protein	Interacting domain	Function	Reference
Scrib
	Mɸ	p22 phox	PDZ4	NADPH complex assembly, ROS production	[7]
	T cell (CD4^+ and CD8^+)	CRTAM	PDZ3	Cdc42/PKCζ polarization, cytokine production	[34]
Dlg1
	Treg	PTEN	PDZ	Akt and NF-κB inhibition	[71]
	T CD8^+	p56 Lck	Prolin rich	Zap 70 and p38 MAPK activation	[45]
	T CD8^+	WASp	SH3	F-Actin polymerization, degranulation	[45]
	T cell	Zap 70	—	Scaffold	[44]
	T cell	WASp	—	Scaffold	[44]
	T cell	p38 MAPK	PDZ	NFAT activation	[72]
	T cell	p56 Lck	Prolin rich	Scaffold	[54]
	T cell	Kv 1.3	PDZ	Scaffold	[54]
	T cell	GAKIN	GUK	Intracellular trafficking	[73]
	B cell	BCR (IgG)	PDZ	p38 activation BCR-downstream signaling	[57]
	DC	Kv 1.3	PDZ	Cytokine production	[8]