Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction

Figure 4

IL-17 induces the secretion of proinflammatory cytokines in monocyte subsets. Human CD14⁺⁺CD16⁻ or CD14⁺⁺CD16⁺/CD14⁺CD16⁺⁺ monocytes were treated with IL-17, IFN-γ, which was used as a positive control, IL-17/IFN-γ, or culture medium alone, which was used as a negative control, for 24 hours. Human CD14⁺⁺CD16⁻in STEMI: (a) TNF-α and (c) IL-6. Human CD14⁺⁺CD16⁻in post-STEMI: (b) TNF-α and (d) IL-6. Human CD14⁺⁺CD16⁺/CD14⁺CD16⁺⁺ monocytes in STEMI: (e) TNF-α and (g) IL-6. CD14⁺⁺CD16⁺/CD14⁺CD16⁺⁺ monocytes post-STEMI: (f) TNF-α and (h) IL-6. Concentrations of TNF-α and IL-6 in the culture supernatants were determined by ELISA. White column: STEMI; black column: post-STEMI; . .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)