BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations
Changes in MDP circulating concentrations after BCG vaccination do not correlate with trained immunity responses. Spearman correlation of MDP fold changes before versus after BCG vaccination correlated with fold changes of cytokine production before versus after BCG vaccination upon ex vivo stimulation with S. aureus and M. tuberculosis (, Spearman correlation). V1 = visit 1 (before vaccination); V2 = visit 2 (two weeks after vaccination); V3 = visit 3 (three months after vaccination). Cells of both rho and value are colored based on rho value. Significant changes are underlined.