Immune Regulation of TNFAIP3 in Psoriasis through Its Association with Th1 and Th17 Cell Differentiation and p38 Activation

<div>Establishment of an imiquimod-induced psoriasis-like dermatitis model in BALB/c mice and the effect of TNF-<i>α</i> antagonists: (a) schematic representation of the experimental plan of with TNF-<i>α</i> antagonists or control rat IgG1 on IMQ-treated mice; (b) representative pictures of IMQ-induced psoriasis-like cutaneous lesions from each group; (c) cumulative scores of the back skin were calculated from each group daily; (d) PASI score in day 7 after IMQ treatment. <span class="nowrap"><svg height="10.7395pt" id="M46" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 56.4993 10.7395" width="56.4993pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 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transform="matrix(.013,0,0,-0.013,43.785,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,50.025,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>;</span> (e) representative hematoxylin and eosin staining of skin sections from each group on day 7 (<span class="nowrap"><svg height="9.51429pt" id="M47" style="vertical-align:-0.2063894pt" version="1.1" viewbox="-0.0498162 -9.3079 74.5083 9.51429" width="74.5083pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M152 404V712C115 698 54 683 7 677V654C71 648 73 642 73 579V24C128 -2 179 -12 220 -12C353 -12 471 92 471 238C471 357 381 449 274 449C262 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Journal of Immunology Research

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Figure 2

Figure 2: Immune Regulation of TNFAIP3 in Psoriasis through Its Association with Th1 and Th17 Cell Differentiation and p38 Activation 