Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ

<div>Effects of cannabidiol on CB2 and GILZ expression in ILC2s. Cell preparations from ischemic-reperfused kidneys of vehicle- (DMSO-) and cannabidiol- (CBD-) treated mice were initially sorted for ILC2s, as described in Methods, followed by their identification as CB2+, GILZ+ ILC2s using both analytical flow cytometry (a, b) and immunofluorescence imaging (c); (b) quantitative data show <svg height="9.10327pt" id="M21" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.75334 72.3287 9.10327" width="72.3287pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M797 0V26C739 32 732 36 732 103V296C732 394 682 449 605 449C576 449 550 437 529 423C504 407 475 389 446 366C425 418 382 449 334 449C303 449 279 437 253 421C222 403 201 385 180 371V452C135 432 85 419 41 411V388C99 379 102 374 102 310V103C102 38 93 32 27 26V0H238V26C189 32 180 38 180 103V338C210 363 250 390 289 390C351 390 377 348 377 275V103C377 37 368 32 306 26V0H520V26C465 32 456 38 456 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Journal of Immunology Research

fig6

Figure 6

Figure 6: Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ 