Research Article

Abnormal Expression of BTLA and CTLA-4 Immune Checkpoint Molecules in Chronic Lymphocytic Leukemia Patients

Figure 6

The effect of in vitro stimulation on mRNA expression levels for BTLA and CTLA-4 (demonstrated as the ratio () of PMA-stimulated to unstimulated expression levels of CTLA-4 and BTLA). (a) Ratio of PMA-stimulated to unstimulated CTLA-4 mRNA expression levels in CD19 cells. (b) Ratio of PMA-stimulated to unstimulated BTLA mRNA expression levels in CD19 cells. (c) Ratio of PMA-stimulated to unstimulated CTLA-4 mRNA expression levels in CD3 cells. (d) Ratio of PMA-stimulated to unstimulated BTLA mRNA expression levels in CD3 cells.