Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model

Figure 3

The inflammatory response was reduced by SIS3 pretreatment in LPS-induced acute lung injury. (a) Histological staining was performed to compare lung injury among the different groups. Both HE staining (upper panel) and Masson’s trichrome staining (lower panel) show drastic leukocyte infiltration in the lung interstitium in the ARDS group, and the leukocyte infiltration was markedly alleviated after treatment of SIS3. Masson’s trichrome staining reveals abnormal fibrosis and collagen distribution which was stained as blue, in the ARDS group, and significantly less blue stain is seen in the ARDS group treated with SIS3. The red triangles indicate the infiltrated sites. The photomicrographs were magnified to 400x. (b) HE staining was used to score lung injury. In the ARDS group, the lung injury was , and after treatment with SIS3, the score decreased to (^★ vs. CTL; ^# vs. ARDS). Data are presented as the ().

(a)

(b)