Research Article
Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model
Figure 5
SIS3 inhibited the protein expression of RAGE, TGF-β1, MMP2, and MMP9 proteins in lung homogenates acquired from ARDS rats. The expression levels of RAGE, TGF-β1, MMP2, and MMP9 proteins in lung tissue homogenates, sera, and BALF of ARDS rats and were determined using western blotting analysis at 24 h after LPS intervention. The results of western blotting showed that SIS3 inhibited LPS-induced (a) RAGE, (b) TGF-β1, (c) MMP2, and (d) and MMP9 protein expression in the lung homogenates. The data are presented as the (). ★ vs. CTL; # vs. ARDS.
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