Research Article
Prealbumin-to-Globulin Ratio Can Predict the Chemotherapy Outcomes and Prognosis of Patients with Gastric Cancer Receiving First-Line Chemotherapy
Table 4
Correlations between survival and the PGR and other clinicopathological factors.
| | Progression-free survival | Overall survival | Univariate analysis | | | Multivariate analysis | | | Univariate analysis | | | Multivariate analysis | | | Hazard ratio | 95% CI | value | Hazard ratio | 95% CI | value | Hazard ratio | 95% CI | value | Hazard ratio | 95% CI | value |
| Sex (male) | 1.073 | 0.835-1.379 | 0.582 | | | | 1.145 | 0.891-1.471 | 0.290 | | | | Age (>60 years) | 0.991 | 0.781-1.256 | 0.939 | | | | 0.797 | 0.627-1.012 | 0.062 | 0.874 | 0.674-1.133 | 0.309 | Body mass index (<18.5 or >25 kg/m2) | 0.923 | 0.705-1.207 | 0.558 | | | | 1.084 | 0.828-1.420 | 0.557 | | | | ECOG (≥2) | 1.124 | 0.823-1.535 | 0.463 | | | | 1.174 | 0.859-1.604 | 0.313 | | | | Histological type (poorly cohesive, mucinous) | 1.492 | 1.136-1.959 | 0.004 | 1.495 | 1.137-1.965 | 0.004 | 1.537 | 1.172-2.015 | 0.002 | 1.407 | 1.067-1.855 | 0.015 | TNM stage (IV) | 1.206 | 0.897-1.622 | 0.214 | | | | 1.368 | 1.017-1.839 | 0.038 | 1.186 | 0.855-1.643 | 0.306 | Number of organs affected by metastasis (≥2) | 1.390 | 1.081-1.786 | 0.010 | 1.400 | 1.077-1.818 | 0.012 | 1.364 | 1.058-1.758 | 0.017 | 1.294 | 0.973-1.721 | 0.077 | Peritoneal metastasis (yes) | 1.526 | 1.185-1.966 | <0.001 | 1.297 | 0.991-1.696 | 0.058 | 1.710 | 1.325-2.205 | <0.001 | 1.426 | 1.062-1.915 | 0.018 | CEA (>5 ng/mL) | 1.222 | 0.959-1.557 | 0.105 | 1.138 | 0.878-1.474 | 0.328 | 1.278 | 1.004-1.626 | 0.046 | 1.299 | 1.004-1.680 | 0.046 | CA72-4 (>6 U/mL) | 1.425 | 1.118-1.816 | 0.004 | 1.411 | 1.091-1.824 | 0.009 | 1.254 | 0.989-1.590 | 0.061 | 1.164 | 0.903-1.501 | 0.240 | CA19-9 (>37 U/mL) | 1.051 | 0.825-1.339 | 0.686 | | | | 1.046 | 0.821-1.332 | 0.717 | | | | Hemoglobin (<115 g/L) | 0.905 | 0.708-1.157 | 0.424 | | | | 0.890 | 0.697-1.136 | 0.349 | | | | PGR ≥7.21 | 0.644 | 0.508-0.817 | <0.001 | 0.672 | 0.527-0.857 | 0.001 | 0.644 | 0.507-0.817 | <0.001 | 0.675 | 0.530-0.861 | 0.002 |
|
|
ECOG: Eastern Cooperative Oncology Group; TNM: tumor-node-metastasis; CEA: carcinoembryonic antigen; CA72-4: carbonhydrate antigen 72-4; CA 19-9: carbohydrate antigen 19-9; PGR: prealbumin-to-globulin ratio.
|