Genetic Mutations of Tim-3 Ligand and Exhausted Tim-3⁺ CD8⁺ T Cells and Survival in Diffuse Large B Cell Lymphoma

Figure 2

The mRNA levels of Tim-3 in tumor and normal tissues from the Oncomine database: (a) upregulation of Tim-3 was found in 8 of 20 cancer types, including lymphoma. (b) Tim-3 mRNA levels were significantly higher in DLBCL cells than normal B cells, including germinal center B-lymphocytes, memory B-lymphocytes, and naïve pregerminal center B-lymphocytes using four probes (1554285_at, 1555628_a_at, 1555629_at, and 235458_at) with the Compagno Lymphoma dataset.

(a)

(b)