Pilot Acute Safety Evaluation of Innocell™ Cancer Immunotherapy in Canine Subjects
Table 1
Results from cytokine analysis of blood samples from three study subjects at various time intervals postadministration of Innocell product. Results include data for immune system-related (GM-CSF, IFN-γ, IL-6, IL-8, IL-15, IP-10, IL-10, TNF-α, and IL-18) and tumor-related (IL-8 and MCP-1) cytokines.
Time posttreatment (hours)
GM-CSF (pg/ml)
IFN-γ (pg/ml)
IL-6 (pg/ml)
IL-8 (pg/ml)
IL-15 (pg/ml)
IP-10 (pg/ml)
IL-10 (pg/ml)
IL-18 (pg/ml)
MCP-1 (pg/ml)
TNF-α (pg/ml)
Subject One
0
7.75
1.45
9.67
7859
53.78
18.25
10.89
27.35
374.58
4.8
8
80.96
34.58
65.02
4168
685.67
19.87
20.09
214.6
309.94
37.06
24
116.18
46.13
100.22
2882
967.45
20.68
18.67
324.23
319.76
56.88
168
50.22
24.71
42.94
2516
525.18
17.44
10.16
138.95
167.86
23.87
Subject Two
0
≤11.1
≤2.37
≤8.02
4105
6.96
15.13
≤8.34
≤10.96
271.7
≤10.39
8
≤11.1
≤2.37
≤8.02
3559
8.32
13.41
≤8.34
≤10.96
316.29
≤10.39
24
≤11.1
≤2.37
≤8.02
3655
2.83
13.01
≤8.34
≤10.96
217.96
≤10.39
Subject Three
0
14.98
≤2.37
10.66
16957
31.59
15.92
≤8.37
12.29
1032
≤10.39
8
18.29
≤2.37
9.35
7419
14.3
17.74
≤8.37
13.29
593.99
≤10.39
24
34.04
≤2.37
17.56
11631
46.63
49.6
≤8.37
21.71
571.2
≤10.39
Values listed as ≤ indicate values below the limit of detection.
