Anti-Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide-Stimulated RAW264.7 Cells

Table 2

Inhibitory effects of compounds (1–17) on LPS-induced NO production.

Compound	IC50 (μM)	Compound	IC50 (μM)
1	4.89 (4.77–5.01)	10	>50
2	38.72 (17.50–85.66)	11	18.07 (10.74–30.42)
3	12.60 (10.65–14.89)	12	39.99 (30.42–52.58)
4	13.13 (9.15–18.84)	13	>50
5	>50	14	>50
6	>50	15	>50
7	>50	16	>50
8	>50	17	>50
9	>50	Dexamethasone^a	0.016 (0.011– 0.023)

The IC₅₀ values are showed with 95% confidence intervals (95% CIs). ^aCytotoxicity was not observed at the IC₅₀ concentration. ^bDexamethasone used as the positive control.