Research Article
Single Nucleotide Polymorphisms in PPARD Associated with Systemic Lupus Erythematosus in Chinese Populations
Table 1
Association analysis of single nucleotide polymorphisms from PPARD gene with susceptibility to systemic lupus erythematosus in Chinese populations.
| Chr. | Gene | SNP | Position (hg19) | Minor allele | Discovery stage (490/493) | Replication stage (1003/815) | Metaanalysis | MAF (case/control %) | value | OR (95% CI) | MAF (case/control %) | value | OR (95% CI) | value | OR (95% CI) |
| 6 | PPARD | rs2267664 | 35312254 | A | 36.7/28.6 | | 1.45 (1.20-1.75) | 30.3/27.4 | 0.05 | 1.16 (1.00-1.34) | | 1.24 (1.11-1.39) | 6 | PPARD | rs4713853 | 35327355 | C | 39.9/32.3 | | 1.39 (1.16-1.68) | 34.9/31.5 | 0.03 | 1.17 (1.02-1.34) | | 1.24 (1.11-1.38) |
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aThe value threshold with Bonferroni correction was less than 0.00294118 when considering 17 variants. |