Single Nucleotide Polymorphisms in PPARD Associated with Systemic Lupus Erythematosus in Chinese Populations

Table 1

Association analysis of single nucleotide polymorphisms from PPARD gene with susceptibility to systemic lupus erythematosus in Chinese populations.

Chr.

Gene

SNP

Position (hg19)

Minor allele

Discovery stage (490/493)

Replication stage (1003/815)

Metaanalysis

MAF (case/control %)

value

OR (95% CI)

MAF (case/control %)

value

OR (95% CI)

value

OR (95% CI)

PPARD

rs2267664

35312254

36.7/28.6

1.45 (1.20-1.75)

30.3/27.4

0.05

1.16 (1.00-1.34)

1.24 (1.11-1.39)

PPARD

rs4713853

35327355

39.9/32.3

1.39 (1.16-1.68)

34.9/31.5

0.03

1.17 (1.02-1.34)

1.24 (1.11-1.38)

^aThe value threshold with Bonferroni correction was less than 0.00294118 when considering 17 variants.