Journal of Immunology Research / 2020 / Article / Tab 2

Research Article

Single Nucleotide Polymorphisms in PPARD Associated with Systemic Lupus Erythematosus in Chinese Populations

Table 2

Stratification analysis for the association between PPARD rs4713853 polymorphism and SLE clinical manifestations.

Clinical manifestationsTT ()CC+CT () value

Gender (male, %)24 (5.6%)47 (8.3%)0.105

Onset age ()0.266

Malar rash (+, %)102 (23.8%)149 (26.2%)0.385

Discoid rash (+, %)2 (0.5%)5 (0.9%)0.697

Photosensitivity (+, %)14 (3.3%)28 (4.9%)0.197

Oral ulcers (+, %)29 (6.8%)43 (7.6%)0.630

Nonerosive arthritis (+, %)118 (27.5%)160 (28.1%)0.830

Pleuritis or pericarditis (+, %)28 (6.5%)54 (9.5%)0.131

Renal disorderSerum creatinine (median, IQR)54 (46-64)56 (48-71)0.002 (0.017a)
24 h proteinuria ()0.423

Pathological classifications (I/II/III/IV/V, %)0(0%)/4(5.3%)/21(28.0%)/23(30.7%)/27(36.0%)1(0.8%)/14(11.2%)/18(14.4%)/49(39.2%)/43(34.4%)0.086

Neurologic disorder (+, %)18 (4.2%)17 (3.0%)0.304

Hematologic disorderHemolytic anemia (+, %)9 (2.1%)9 (1.6%)0.544
Leukopenia (+, %)98 (23.5%)149 (26.2%)0.276
Lymphopenia (+, %)173 (41.7%)230 (41.3%)0.902
Thrombocytopenia (+, %)98 (23.6%)145 (25.9%)0.404

Immunologic disorderAnti-dsDNA (+, %)238 (61.8%)331 (64.1%)0.473
Anti-Sm (+, %)45 (14.2%)87 (20.0%)0.039 (0.042b)
C30.082
C40.271

SLEDAI ()0.601

a value calculated using the quartile of serum creatinine under the logistic regression model. b value calculated under the logistic regression model.

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