Genetic Background of Hypertension in Connective Tissue Diseases

Table 2

Allele frequency distribution and logistic regression analysis (with odds ratio (OR) and 95% confidence interval (CI)) for the associations of the studied PPAR gamma-2 and ADRB3 polymorphisms with CTD vs. control group and hypertension (HA) vs. normal blood pressure.

PPARγ polymorphisms
Alleles	(frequency)		Logistic regression analysis
rs1801282	CTD ()	Control group ()	OR (95% CI)
Pro	174 (0.84)	169 (0.82)	1^1
Ala	34 (0.16)	37 (0.18)	0.8925 (0.5351-1.489)	0.6629
	Hypertensive ()	Normotensive ()	OR (95% CI)
Pro	146 (0.82)	196 (0.83)	1^1
Ala	32 (0.18)	40 (0.17)	1.074 (0.6436-1.792)	0.7846
rs3856806	CTD	Controls	OR (95% CI)
C1431	181 (0.87)	168 (0.82)	1^1
T1431	27 (0.13)	38 (0.18)	0.6595 (0.3858-1.127)	0.1264
	Hypertensive	Normotensive	OR (95% CI)
C1431	153 (0.86)	196 (0.83)	1^1
T1431	25 (0.14)	40 (0.17)	0.8007 (0.4653-1.378)	0.4213
ADRB3 polymorphism
Alleles	(frequency)		Logistic regression analysis
rs4994	CTD	Controls	OR (95% CI)
Trp64	190 (0.91)	195 (0.95)	1^1
Arg64	18 (0.09)	11 (0.05)	1.679 (0.7726-3.651)	0.1865
	Hypertensive	Normotensive	OR (95% CI)
Trp64	162 (0.91)	223 (0.94)	1^1
Arg64	16 (0.09)	13 (0.06)	1.694 (0.7927-3.621)	0.1696

¹Reference category; OR (95% CI): odds ratio (95% confidence interval).