Association of Neutrophil–Lymphocyte Ratio and the Presence of Neonatal Sepsis
Table 1
Baseline characteristics of control, infection, and sepsis group.
Variables
Controls ()
Infection ()
Sepsis ()
Age (days)
7.0 (5.0, 12.0)
7.0 (4.0, 12.0)
10.0 (5.0, 17.0)bc
<0.001
Male, (%)
115 (61.2%)
318 (57.3%)
453 (61.5%)
0.295
Weight (kg)
c
0.014
Temperature (°C)
bc
<0.001
Respiratory (rate/minute)
bc
<0.001
Heart rate (bpm)
bc
<0.001
SBP (mm Hg)
0.439
DBP (mm Hg)
0.063
PCT (ng/mL)
0.11 (0.09, 0.18)
0.14 (0.10, 0.25)a
0.31 (0.14, 1.52)bc
<0.001
hsCRP (mg/L)
0.7 (0.7, 0.7)
0.7 (0.7, 0.7)
0.7 (0.7, 13.48)bc
<0.001
Biochemical parameters
TBIL (μmol/L)
306.4 (262.3, 357.7)
298.2 (230.9, 355.8)a
132.0 (45.4, 216.1)bc
<0.001
AST (U/L)
34.4 (28.5, 46.8)
37.9 (30.2, 51.0)a
38.5 (27.9, 55.2)
0.078
ALT (U/L)
24.3 (17.6, 30.3)
25.5 (20.0, 33.2)
28.5 (21.8, 37.8)bc
<0.001
TP (g/L)
bc
<0.001
ALB (g/L)
bc
<0.001
UREA (mmol/L)
2.2 (1.3, 2.9)
2.3 (1.5, 3.2)
3.1 (1.9, 4.4)bc
<0.001
CREA (μmol/L)
49.6 (41.0, 57.9)
51.0 (42.0, 59.3)
47.3 (37.4, 63.1)c
0.057
UA (μmol/L)
135.5 (104.9, 186.5)
137.9 (103.1, 182.5)
147.8 (109.9, 205.0)bc
0.003
Hematologic parameters
WBC (109 cells/L)
9.45 (7.92, 11.67)
10.03 (8.10, 12.39)
9.99 (7.27, 14.13)
0.253
Neutrophil count (109 cells/L)
3.72 (2.82, 5.49)
4.29 (3.16, 6.07)a
5.07 (3.07, 8.58)bc
<0.001
Lymphocyte count (109 cells/L)
4.10 (3.15, 4.86)
3.94 (2.95, 5.18)
3.34 (2.11, 4.78)bc
<0.001
NLR
0.92 (0.63, 1.45)
1.07 (0.75, 1.84)a
1.65 (0.85, 3.07)bc
<0.001
All values are presented as the or (%) or as the median (interquartile range). SBP, systolic blood pressure; DBP, diastolic blood pressure; PCT, procalcitonin; TBIL, total bilirubin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TP, total protein; ALB, albumin; UREA, urea nitrogen; CREA, creatinine; UA, uric acid; WBC, white blood cell; hsCRP, high-sensitivity C-reactive protein; NLR, neutrophil-to-lymphocyte ratio. a for infection vs. control. b for sepsis vs. control. c for sepsis vs. infection.
