Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation

<div>Expanded human Treg maintain their suppressive capacity <i>in vitro</i>. (a) Schematic representation of the huPBL-SCID-huSkin allograft model with adoptive transfer of PBMC combined with or without Treg (1 : 1 ratio). (b) Flow cytometric analysis of Treg before and after expansion. Representative dot plot showing CD25 and FOXP3 expression of input cells and expanded human Treg, respectively. (c) Suppressive capacity of the <i>ex vivo</i>-expanded Treg was examined using an <i>in vitro</i> suppression assay. 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Journal of Immunology Research

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Figure 1

Figure 1: Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation 

Figure 1 | Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation 