Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice

Figure 1

UBA1 expression was upregulated and mainly derived from macrophages in the atherosclerotic plaques of Apoe-/- mice. (a) Expression of UBA1 in the vessels with (right) or without atherosclerotic plaques (left). (b) Colocalization of UBA1 with the macrophage marker CD68 in the atherosclerotic plaques.

(a)

(b)