Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice

Figure 2

Inhibition of UBA1 did not alter the main metabolic parameters during diet-induced atherogenesis in Apoe-/- mice. (a) Plasma total cholesterol and triglyceride levels before and after the atherogenic diet feeding. (b) Plasma lipoprotein profiles fractioned by FPLC before (left) and after (right) the atherogenic diet feeding. (c) Plasma glucose levels before and after the atherogenic diet feeding. (d) Insulin resistance detected by the glucose tolerance test after 8 weeks on the atherogenic diet. (e) Body weight gain during the atherogenic diet feeding. per group; ns: not significant; ATD: atherogenic diet.

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