Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice

Figure 3

Inhibition of UBA1 attenuated diet-induced atherosclerosis in Apoe-/- mice. (a, b) Oil red O staining and quantitation of the atherosclerotic burden in the en face aorta (a) and the aortic root (b). (c) CD68 immunochemical staining and quantitation of the lesional macrophages in the aortic root. (d) α-SMA immunochemical staining and quantitation of the lesional smooth muscle cells in the aortic root. (e) HE staining and quantitation of the lesional necrotic areas in the aortic root. per group; : <0.05; ns: not significant.

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