Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice

Figure 5

Inhibition of UBA1 decreased cellular oxidative stress in diet-induced atherosclerosis in Apoe-/- mice. (a) Quantitative real-time PCR analysis of aortic expression of NADPH oxidases (Nox1, Nox2, and Nox4). (b) DHE staining and quantitation of the lesional oxidative stress level in the aortic root. per group; : <0.05.

(a)

(b)