Elevated Levels of Activated and Pathogenic Eosinophils Characterize Moderate-Severe House Dust Mite Allergic Rhinitis

Figure 4

Levels of eosinophil progenitors in the peripheral blood are increased in patients with moderate-severe allergic rhinitis. (a) Gating strategy for of leukocyte progenitors (live CD45RA-CD34⁺ cells) and eosinophil progenitors (live CD45RA-CD34⁺CD125⁺CD38⁺ cells) in the peripheral blood. (b) Levels of leukocyte progenitors and eosinophil progenitors in the peripheral blood of healthy controls, mild allergic rhinitis, and moderate-severe allergic rhinitis. Progenitor levels are expressed in absolute numbers per one million PBMCs. (b) Correlation of leukocyte progenitor and eosinophil progenitor absolute numbers in patients with allergic rhinitis in the peripheral blood with TNSS. HC: healthy controls; M-AR: mild allergic rhinitis; MS-AR: moderate-severe allergic rhinitis; PBMCs: peripheral blood mononuclear cells; FMO: fluorescence minus one control; EoP: eosinophil progenitor.

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