Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis

Figure 3

Comparison of DEG of the nonchondrocyte cluster from healthy and OA patients. (a) Volcano plot comparing the gene expression between healthy and OA monocyte clusters. (b) Volcano plot comparing the gene expression between healthy and OA endothelial cell clusters. (c) Volcano plot comparing the gene expression between healthy and OA macrophage clusters. Each plot represents one gene. Threshold of Log₂ fold change has been set as 0.3. (d) Dot plot showing the enrichment of Gene Ontology biological processes in the upregulated monocyte DEG between healthy and OA tissues. (e) Dot plot showing the enrichment of Gene Ontology biological processes in the downregulated monocyte DEG between healthy and OA tissues. (f) Dot plot showing the enrichment of Gene Ontology biological processes in the upregulated endothelial cell DEG between healthy and OA tissues. (g) Dot plot showing the enrichment of Gene Ontology biological processes in the upregulated macrophage DEG between healthy and OA tissues.

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