Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed?

Figure 1

Strategy to assess the functionality of innate and adaptive immunity. (a) Innate receptors TLR2, TLR4, TLR9, NOD1, and NOD2 were stimulated with their synthetic ligands for the production of IL-8. IFN-γ receptor was stimulated with rhIFN-γ for the production of TNF-α. (b) IL-12 receptor was stimulated with rhIL-12 for the production of IFN-γ. (c) The cellular risk for oxidative damage was determined by measuring the extracellular reduced glutathione (GSH) in plasma.

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