Persistent Activation of Innate Immunity in Patients with Primary Antibody Deficiencies

Figure 2

(a) Monocyte absolute numbers (per μL) of whole peripheral blood of the patients and controls of the study. (b) Representative dot plots of CD16 expression on whole-blood monocytes at basal state. (c) CD16 percentile expression on monocytes of the patients and controls of the study. (d) Percentages of classical, intermediate, and non-classical subpopulations within the monocyte population in whole-blood basal state condition, for the patients and controls of the study: White columns represent classical monocytes, black columns the intermediate monocytes, and grey columns the non-classical monocytes. (e) Absolute numbers of classical, (f) intermediate, (g) and non-classical monocytes. (h) Correlation of CD64 percentage of expression on PMN to CD16 percentage of expression on monocytes on healthy controls and (i) in PAD patients. Statistical analyses were performed by the Mann–Whitney test and Spearman correlation analysis; ; ; ns, not significant.