TILs and Anti-PD1 Therapy: An Alternative Combination Therapy for PDL1 Negative Metastatic Cervical Cancer

Figure 4

Univariate analyses of more infusion (TIL numbers and CD8⁺TIL percentage), less infusion (CD8⁺PD1⁺ TIL percentage and CD4⁺FoxP3⁺TIL percentage), and HPV status and having fever or not after immunotherapy based on PFS. PFS curve for: (a) patients with more TIL numbers (≥, red line) and less TIL numbers (<, blue line); (b) patients with more CD8⁺ TIL (≥60%, red line) and less CD8⁺ TIL (<60%, blue line); (c) patients with more CD8⁺PD1⁺ TIL (≥10%, red line) and less CD8⁺PD1⁺ TIL (<10%, blue line); (d) patients with more CD4⁺FoxP3⁺ TIL (≥20%, red line) and less CD4⁺FoxP3⁺ TIL (<20%, blue line); (e) patients with HPV⁺ (red line) and HPV^- (blue line); and (f) patients having fever (red line) and no fever (blue line) after immunotherapy.

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