Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population

Table 1

The association between NCF2, NCF4, and CYBA gene polymorphisms and RA susceptibility among different groups ( (%)).

SNP	Analyze model	RA patients	Controls	value	OR (95% CI)
All
rs10911363	GG	125 (21.08)	144 (24.16)	0.371	0.863 (0.625, 1.192)
	GT	304 (51.26)	289 (48.49)	0.747	1.045 (0.798, 1.370)
	TT	164 (27.66)	163 (27.35)	Reference
	G	554 (46.71)	577 (48.41)	0.408	1.070 (0.911, 1.257)
	T	632 (53.29)	615 (51.59)	Reference
	TT	164 (27.66)	163 (27.35)	0.906	1.016 (0.787, 1.310)
	GT+GG	429 (72.34)	433 (72.65)	Reference
	GG	125 (21.08)	144 (24.16)	0.204	0.838 (0.639, 1.101)
	GT+TT	468 (78.92)	452 (75.84)	Reference
rs3794624	AA	14 (2.36)	15 (2.52)	0.929	0.967 (0.461, 2.027)
	GA	160 (26.98)	147 (24.66)	0.368	1.127 (0.868, 1.464)
	GG	419 (70.66)	434 (72.82)	Reference
	A	188 (15.85)	177 (14.85)	0.498	1.080 (0.864, 1.350)
	G	998 (84.15)	1015 (85.15)	Reference
	GG	419 (70.66)	434 (72.82)	0.408	0.899 (0.698, 1.157)
	GA+AA	174 (29.34)	162 (27.18)	Reference
	AA	14 (2.36)	15 (2.52)	0.862	0.937 (0.448, 1.958)
	GA+GG	579 (97.64)	581 (97.48)	Reference
rs4673	AA	1 (0.17)	5 (0.84)	0.140	0.198 (0.023, 1.698)
	GA	85 (14.33)	90 (15.10)	0.673	0.933 (0.677, 1.287)
	GG	507 (85.50)	501 (84.06)	Reference
	A	87 (7.34)	100 (8.39)	0.340	0.864 (0.641, 1.166)
	G	1099 (92.66)	1092 (91.61)	Reference
	GG	507 (85.50)	501 (84.06)	0.491	1.118 (0.814, 1.535)
	GA+AA	86 (14.50)	95 (15.94)	Reference
	AA	1 (0.17)	5 (0.84)	0.142	0.200 (0.023, 1.714)
	GA+GG	592 (99.83)	591 (99.16)	Reference
rs1883112	GG	57 (9.61)	56 (9.39)	0.972	1.007 (0.673, 1.508)
	GA	248 (41.82)	255 (42.79)	0.754	0.962 (0.757, 1.223)
	AA	288 (48.57)	285 (47.82)	Reference
	G	362 (30.52)	367 (30.79)	0.888	0.988 (0.830, 1.176)
	A	824 (69.48)	825 (69.21)	Reference
	AA	288 (48.57)	285 (47.82)	0.796	1.030 (0.821, 1.294)
	GA+GG	305 (52.43)	311 (52.18)	Reference
	GG	57 (9.61)	56 (9.40)	0.899	1.025 (0.696, 1.511)
	GA+AA	536 (90.39)	540 (90.60)	Reference
rs4821544	CC	4 (0.67)	7 (1.17)	0.323	0.536 (0.156, 1.845)
	CT	117 (19.73)	146 (24.50)	0.043	0.752 (0.571, 0.991)
	TT	472 (79.60)	443 (74.33)	Reference
	C	125 (10.54)	160 (13.42)	0.031	1.316 (1.026, 1.688)
	T	1061 (89.46)	1032 (86.58)	Reference
	TT	472 (79.60)	443 (74.33)	0.031	0.742 (0.566, 0.974)
	CT+CC	121 (20.40)	153 (25.67)	Reference
	CC	4 (0.67)	7 (1.17)	0.374	0.571 (0.166, 1.962)
	CT+TT	589 (99.33)	589 (98.83)	Reference
rs729749	TT	104 (17.54)	102 (17.11)	0.445	0.878 (0.628, 1.226)
	CT	266 (44.86)	302 (50.67)	0.033	0.758 (0.588, 0.977)
	CC	223 (37.61)	192 (32.21)	Reference
	T	474 (39.97)	506 (42.45)	0.219	0.903 (0.767, 1.063)
	C	712 (60.03)	686 (57.55)	Reference
	CC	223 (37.61)	192 (32.21)	0.051	1.268 (0.999, 1.611)
	CT+TT	370 (62.39)	404 (67.79)	Reference
	TT	104 (17.54)	102 (17.11)	0.847	1.030 (0.763, 1.391)
	CT+CC	489 (82.46)	494 (82.89)	Reference
Female
rs10911363	GG	104 (21.14)	117 (23.45)	0.548	0.896 (0.625, 1.283)
	GT	259 (52.64)	252 (50.50)	0.818	1.036 (0.768, 1.397)
	TT	129 (26.22)	130 (26.05)	Reference
	G	467 (47.46)	486 (48.70)	0.581	1.051 (0.881, 1.253)
	T	517 (52.54)	512 (51.30)	Reference
	TT	129 (26.22)	130 (26.05)	0.952	0.991 (0.747, 1.316)
	GT+GG	363 (73.78)	369 (73.95)	Reference
	GG	104 (21.14)	117 (23.45)	0.383	1.143 (0.847, 1.542)
	GT+TT	388 (78.86)	382 (76.55)	Reference
rs3794624	AA	12 (2.44)	12 (2.40)	0.876	1.067 (0.473, 2.407)
	GA	137 (27.85)	121 (24.25)	0.194	1.208 (0.908, 1.607)
	GG	343 (69.72)	366 (73.35)	Reference
	A	161 (16.36)	145 (14.53)	0.259	0.869 (0.681, 1.109)
	G	823 (83.64)	853 (85.47)	Reference
	GG	343 (69.72)	366 (73.35)	0.205	1.195 (0.907, 1.576)
	GA+AA	149 (30.28)	133 (26.65)	Reference
	AA	12 (2.44)	12 (2.40)	0.972	0.986 (0.438, 2.216)
	GA+GG	480 (97.56)	487 (97.60)	Reference
rs4673	AA	1 (0.20)	5 (1.00)	0.140	0.198 (0.023, 1.703)
	GA	70 (14.23)	77 (15.43)	0.558	0.900 (0.634, 1.279)
	GG	421 (85.57)	417 (83.57)	Reference
	A	72 (7.32)	87 (8.72)	0.252	1.210 (0.874, 1.675)
	G	912 (92.68)	911 (91.28)	Reference
	GG	421 (85.57)	417 (83.57)	0.346	0.847 (0.600, 1.196)
	GA+AA	71 (14.43)	83 (16.63)	Reference
	AA	1 (0.20)	5 (1.00)	0.144	4.970 (0.579, 42.692)
	GA+GG	491 (99.8)	494 (99.00)	Reference
rs1883112	GG	41 (8.33)	47 (9.42)	0.630	0.894 (0.567, 1.409)
	GA	211 (42.89)	206 (41.28)	0.715	1.050 (0.808, 1.364)
	AA	240 (48.78)	246 (49.30)	Reference
	G	293 (29.78)	300 (30.06)	0.890	1.014 (0.836, 1.229)
	A	691 (70.22)	698 (69.94)	Reference
	AA	240 (48.78)	246 (49.30)	0.870	1.021 (0.796, 1.310)
	GA+GG	252 (51.22)	253 (50.70)	Reference
	GG	41 (8.33)	47 (9.42)	0.548	1.144 (0.738, 1.774)
	GA+AA	451 (91.67)	452 (90.58)	Reference
rs4821544	CC	4 (0.81)	6 (1.20)	0.494	0.641 (0.180, 2.290)
	CT	95 (19.31)	115 (23.05)	0.141	0.795 (0.585, 1.079)
	TT	393 (79.88)	378 (75.75)	Reference
	C	103 (10.47)	127 (12.73)	0.117	1.247 (0.946, 1.644)
	T	881 (89.53)	871 (87.27)	Reference
	TT	393 (79.88)	378 (75.75)	0.118	0.787 (0.583, 1.063)
	CT+CC	99 (20.12)	121 (24.25)	Reference
	CC	4 (0.81)	6 (1.20)	0.540	1.485 (0.416, 5.294)
	CT+TT	488 (99.19)	493 (98.80)	Reference
rs729749	TT	84 (17.07)	87 (17.43)	0.469	0.873 (0.604, 1.261)
	CT	231 (46.95)	252 (50.50)	0.186	0.829 (0.627, 1.095)
	CC	177 (35.98)	160 (32.06)	Reference
	T	399 (40.55)	426 (42.69)	0.335	1.092 (0.913, 1.306)
	C	585 (59.45)	572 (57.31)	Reference
	CC	177 (35.98)	160 (32.06)	0.194	0.840 (0.646, 1.093)
	CT+TT	315 (64.02)	339 (67.94)	Reference
	TT	84 (17.07)	87 (17.43)	0.880	1.026 (0.738, 1.426)
	CT+CC	408 (82.93)	412 (82.57)	Reference
Male
rs10911363	GG	21 (20.79)	27 (27.84)	0.413	0.733 (0.349, 1.541)
	GT	45 (44.55)	37 (38.14)	0.677	1.147 (0.602, 2.184)
	TT	35 (34.65)	33 (34.02)	Reference
	G	87 (43.07)	91 (46.91)	0.443	1.168 (0.786, 1.736)
	T	115 (56.93)	103 (53.09)	Reference
	TT	35 (34.65)	33 (34.02)	0.925	0.972 (0.541, 1.749)
	GT+GG	66 (65.35)	64 (65.98)	Reference
	GG	21 (20.79)	27 (27.84)	0.249	1.469 (0.764, 2.827)
	GT+TT	80 (79.21)	70 (72.16)	Reference
rs3794624	AA	2 (1.98)	3 (3.09)	0.578	0.596 (0.097, 3.677)
	GA	23 (22.77)	26 (26.8)	0.480	0.791 (0.413, 1.515)
	GG	76 (75.25)	68 (70.1)	Reference
	A	27 (13.37)	32 (16.49)	0.383	1.280 (0.735, 2.230)
	G	175 (86.63)	162 (83.51)	Reference
	GG	76 (75.25)	68 (70.1)	0.417	0.771 (0.412, 1.444)
	GA+AA	25 (24.75)	29 (29.9)	Reference
	AA	2 (1.98)	3 (3.09)	0.621	1.580 (0.258, 9.666)
	GA+GG	99 (98.02)	94 (96.91)	Reference
rs4673	AA	0	0	—	—
	GA	15 (14.85)	13 (13.40)	0.770	1.127 (0.506, 2.511)
	GG	86 (85.15)	84 (86.60)	Reference
	A	15 (7.43)	13 (6.70)	0.779	0.895 (0.414, 1.934)
	G	187 (92.57)	181 (93.30)	Reference
rs1883112	GG	16 (15.84)	9 (9.28)	0.433	1.444 (0.576, 3.623)
	GA	37 (36.63)	49 (50.52)	0.111	0.614 (0.336, 1.119)
	AA	48 (47.52)	39 (40.21)	Reference
	G	69 (34.16)	67 (34.54)	0.937	1.017 (0.672, 1.540)
	A	133 (65.84)	127 (65.46)	Reference
	AA	48 (47.52)	39 (40.21)	0.300	0.742 (0.423, 1.304)
	GA+GG	53 (52.48)	58 (59.79)	Reference
	GG	16 (15.84)	9 (9.28)	0.169	0.543 (0.228, 1.296)
	GA+AA	85 (84.16)	88 (90.72)	Reference
rs4821544	CC	0	1 (1.03)	1.000	—
	CT	22 (21.78)	31 (31.96)	0.098	0.584 (0.309, 1.104)
	TT	79 (78.22)	65 (67.01)	Reference
	C	22 (10.89)	33 (17.01)	0.081	1.677 (0.939, 2.995)
	T	180 (89.11)	161 (82.99)	Reference
	TT	79 (78.22)	65 (67.01)	0.078	0.566 (0.300, 1.067)
	CT+CC	22 (21.78)	32 (32.99)	Reference
	CC	0	1 (1.03)	1.000	—
	CT+TT	101 (100.00)	96 (98.97)	Reference
rs729749	TT	20 (19.8)	15 (15.46)	0.855	0.928 (0.414, 2.079)
	CT	35 (34.65)	50 (51.55)	0.024	0.487 (0.261, 0.909)
	CC	46 (45.54)	32 (32.99)	Reference
	T	75 (37.13)	80 (41.24)	0.403	1.188 (0.793, 1.780)
	C	127 (62.87)	114 (58.76)	Reference
	CC	46 (45.54)	32 (32.99)	0.072	0.589 (0.331, 1.041)
	CT+TT	55 (54.46)	65 (67.01)	Reference
	TT	20 (19.80)	15 (15.46)	0.425	0.741 (0.355, 1.547)
	CT+CC	81 (80.20)	82 (84.54)	Reference