Research Article
Systemic Inflammation Response Index Predicts Survival Outcomes in Glioblastoma Multiforme Patients Treated with Standard Stupp Protocol
Table 1
Baseline demographics per SIRI status.
| | Characteristic | All patients () | () | () | value |
| | Median age, y (range) | 59 (24-80) | 60 (32-79) | 58 (24-80) | 0.54 | | Age group, (%) | | | | | | <50 years | 57 (31.5) | 30 (31.3) | 27 (31.8) | 0.88 | | ≥50 years | 124 (68.5) | 66 (68.7) | 58 (68.2) | | | Gender, (%) | | | | | | Female | 65 (35.9) | 34 (35.4) | 31 (36.5) | 0.84 | | Male | 116 (64.1) | 62 (64.6) | 54 (63.5) | | | KPS, (%) | | | | | | 90-100 | 98 (54.1) | 55 (57.3) | 43 (50.6) | 0.17 | | 70-80 | 83 (45.9) | 41 (42.7) | 42 (49.4) | | | Presenting symptoms | | | | | | Focal sensory-motor deficit | 96 (53.0) | 49 (51.0) | 47 (55.3) | 0.49 | | Cognitive deficits | 44 (24.3) | 23 (24.0) | 21 (24.7) | | | Increased ICP | 31 (17.1) | 19 (19.8) | 12 (14.1) | | | Others | 10 (5.6) | 5 (5.2) | 5 (5.9) | | | Symptom duration, (%) | | | | | | <3 months | 129 (71.3) | 71 (74.0) | 58 (68.2) | 0.28 | | ≥3 months | 52 (28.7) | 25 (26.0) | 27 (31.8) | | | Corticosteroid use, (%) | | | | | | Yes | 119 (65.7) | 59 (61.5) | 60 (70.6) | 0.08 | | No | 62 (34.3) | 37 (38.5) | 25 (29.4) | | | Anticonvulsant use, (%) | | | | | | Yes | 67 (37.0) | 35 (36.5) | 32 (37.6) | 0.90 | | No | 114 (63.0) | 61 (63.5) | 53 (62.4) | | | Tumor location, (%) | | | | | | Frontal | 39 (21.5) | 20 (20.8) | 19 (22.4) | 0.53 | | Parietal | 32 (17.8) | 15 (15.7) | 17 (20.0) | | | Temporal | 37 (20.4) | 20 (20.8) | 17 (20.0) | | | Occipital | 19 (10.5) | 11 (11.5) | 8 (9.4) | | | Midline | 19 (10.5) | 10 (10.4) | 9 (10.5) | | | Multilobar | 35 (19.3) | 20 (20.8) | 15 (17.7) | | | Extent of surgery, (%) | | | | | | GTR | 67 (37.0) | 37 (38.5) | 30 (35.3) | 0.66 | | STR | 79 (43.7) | 42 (43.8) | 37 (43.5) | | | Biopsy | 35 (19.3) | 17 (17.7) | 18 (21.2) | | | IDH status | | | | | | Positive | 10 (10.8) | 5 (10.4) | 5 (11.1) | 0.78 | | Negative | 83 (89.2) | 43 (89.6) | 40 (88.9) | | | RTOG RPA class, (%) | | | | | | III | 69 (38.1) | 37 (38.5) | 32 (37.6) | 0.74 | | IV | 77 (42.5) | 42 (43.3) | 35 (41.2) | | | V | 35 (19.4) | 17 (18.2) | 18 (21.2) | |
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IDH status was available in 93 patients. Abbreviations: SIRI: systemic immune response index; KPS: Karnofsky performance score; ICP: intracranial pressure; GTR: gross total resection; STR: subtotal resection; IDH: isocitrate dehydrogenase; RTOG RPA: radiation therapy oncology group recursive partitioning analysis. |
