Major Histocompatibility Complex Genes as Therapeutic Opportunity for Immune Cold Molecular Cancer Subtypes

Figure 2

Results of unsupervised clustering of expression probabilities of MHC genes. Major molecular cancer subtypes (-axis) are portrayed by overlaying MHC expression clusters (MHC-low, MHC-intermediate, and MHC-high) together with expression probabilities of immunoinhibitors and CAGs, frequencies of nonsynonymous mutations (other/MUTsum), and levels of T CD4 and T CD8 (other/TCD4 and TCD8). Expression probability for each variable in each cancer subtype can be described as lower (0-0.4), not changed (0.5), and higher (0.6-1).