The Role of Inflammation in Crohn’s Disease Recurrence after Surgical Treatment

Table 2

New perspectives for recurrence prevention.

Domain	Prevention strategy	Description	Rationale
Medical	Fecal transplantation	Transfer of fecal bacteria from healthy subjects	Avoid dysbiosis reestablishment
Medical	Hematopoietic stem cell transplantation	Bone marrow ablation followed by autotransplantation of multipotent stem cells	Reset immune system
Surgical	Michelassi strictureplasty	Side-to-side isoperistaltic strictureplasty	Induce mucosal healing by resolution of chronic obstruction
Surgical	Kono anastomosis	Fashioning of antimesenteric wide lumen anastomosis	Increase the diameter and stability/durability of anastomosis
Surgical	Mesenteric excision	Excision of the associated mesentery	Removal of pathological tissue
Surgical	Pathophysiological excision	Excision of draining mesenteric lymph nodes	Removal of most memory T-cells, drivers of inflammation and recurrence