Tumor-Infiltrating Immune Cells and PD-L1 as Prognostic Biomarkers in Primary Esophageal Small Cell Carcinoma

Table 2

Univariate and multivariate analyses for overall survival in PESCC.

Prognostic factor	Univariate analysis			Multivariate analysis
	HR	95% CI		HR	95% CI
Sex
Male vs. female	0.682	0.389-1.194	0.180
Age
≤60 vs. >60	1.384	0.818-2.342	0.226
Location
Upper third vs. middle and lower thirds	1.134	0.486-2.647	0.771
^aT classification
T1-2 vs. T3-4	1.964	1.148-3.359	0.014
^aN classification
N0 vs. N1-2	0.363	0.207-0.637	<0.001
^aM classification
M0 vs. M1	3.933	1.945-7.950	<0.001
^aStage
I-II vs. III-IV	2.493	1.463-4.248	0.001	2.334	1.323-4.118	0.003
Necrosis
No vs. yes	1.761	1.027-3.021	0.040
^bTIIs
Poor vs. rich	0.628	0.378-1.044	0.073
CD4
Poor vs. rich	1.696	0.981-2.934	0.059	1.935	1.068-3.507	0.030
FoxP3
Poor vs. rich	1.807	1.038-3.145	0.036
CD8
Poor vs. rich	0.568	0.312-1.033	0.064
CD163
Poor vs. rich	0.762	0.432-1.345	0.349
PD-L1
Negative vs. positive	0.578	0.333-1.000	0.050	0.480	0.267-0.860	0.014
FoxP3/CD8
Low vs. high	1.842	1.091-3.108	0.022	1.727	1.015-2.938	0.044
CD8/CD4
Low vs. high	0.590	0.344-1.012	0.055

^aTNM stage: the AJCC (8th edition) was used; ^bTIIs: tumor-infiltrating immune cells.