Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico Analysis

Figure 3

(a) Here, we show the interaction pose of a representative complex of the vaccine-TLR3 refined cluster. The designed vaccine is colored red while the TLR3 structure is colored dark green. The interacting residues are focused, and some interchain hydrogen bonds are highlighted. Residues Tyr198, Lys200, and Asn210 of the vaccine construct participated in hydrogen bond formation with some residues in the TLR3 structure. (b) Interacting residues as well as bonding interactions between the vaccine and TLR3 protein chains.

(a)

(b)