Identification of Long Noncoding RNAs lnc-DC in Plasma as a New Biomarker for Primary Sjögren’s Syndrome

Table 1

The basic characteristics, clinical manifestations and laboratory findings of pSS patients with and without ITP.

Characteristic	pSS without ITP ()	pSS with ITP ()		value
Basic characteristics
Age (years)			-0.242 ^a	0.809
Gender (female/male)	121/6	20/2	0.107^b	0.744
Clinical manifestations
Dry mouth (%)	85/118 (72.03)	11/20 (55.00)	2.344^b	0.126
Dry eye (%)	60/118 (50.85)	6/20 (30.00)	2.979^b	0.084
Arthritis (%)	41/110 (37.27)	3/19 (15.79)	3.327^b	0.068
Interstitial lung disease (%)	58/108 (53.70)	5/17 (29.41)	3.467^b	0.063
ESSDAI	4.00 (2.00–6.00)	5.00 (3.00–7.00)	-2.135^c	0.033
Laboratory findings
lnc-DC, IU/mL			-33.041^a	<0.001
Platelet, ×109/L			22.384^c	<0.001
Hemoglobin, g/L			0.522^c	0.602
Leukocyte, ×109/L			-0.776^c	0.438
Creatinine, mg/dL			1.985^c	0.047
ALT, U/L			-0.950^c	0.342
AST, U/L			-1.232^c	0.218
Positive ANA (%)	93/116 (80.17)	15/20 (75.00)	0.052^b	0.819
Positive AHA (%)	2/121 (16.67)	2/18 (11.11)	—	0.081^d

Data are presented as (standard deviation) or median with 25–75th percentiles, positive number/tested number (%). ESSDAI: European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index; ALT: alanine aminotransferase; AST: aspartate aminotransferase; Anna: antinuclear antibody; aha: anti-histone antibody. was considered statistically significant. ^aIndependent sample -test; ^bchi-squared test; ^cMann–Whitney test; ^dFisher exact probability method.