Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

Table 2

Characteristics of included studies on IL-10 gene polymorphisms and Behcet’s disease risk.

First author	Year	Country/region	Racial	Source of controls	Case	Control	Genotype distribution						Genotyping methods	for HWE	NOS
							Case			Control
							-1082A>G (rs1800896)
							AA	AG	GG	AA	AG	GG
Wallace-1	2007	UK	Europe	HB	63	182	27	23	13	59	75	48	PCR-SSP	0.02	5
Wallace-2	2007	Jordan and Palestinian	ME	HB	115	113	50	50	15	46	40	27	PCR-SSP	<0.01	5
Dilek	2009	Turkey	ME	PB	96	124	26	66	4	56	58	10	PCR-SSP	0.35	8
Ates	2010	Turkey	ME	PB	102	102	39	50	13	44	50	8	ARMS-PCR	0.23	7
Shahram	2011	Iran	ME	HB	147	140	58	81	8	53	75	12	PCR-SSP	0.04	5
Talaat	2014	Egypt	ME	HB	87	97	32	34	21	32	53	12	MS-PCR	0.16	6
Hu-1	2015	China	EA	PB	300	350	271	29	0	293	56	1	PCR-RFLP	0.32	10
Al-Okaily	2015	Saudi Arabia	ME	PB	61	211	14	37	10	36	159	16	ARMS-PCR	<0.01	7
Barış	2016	Turkey	ME	HB	71	70	98^a	44^b		99^a	41^b		PCR-RFLP	NA	4
							-819T>C (rs1800871)
							TT	TC	CC	TT	TC	CC
Wallace-1	2007	UK	Europe	HB	63	182	7	28	44	13	67	102	PCR-SSP	0.66	6
Wallace-2	2007	Jordan and Palestinian	ME	HB	115	113	11	61	43	10	43	60	PCR-SSP	0.57	6
Dilek	2009	Turkey	ME	PB	96	124	7	50	39	13	47	64	PCR-SSP	0.33	8
Ates	2010	Turkey	ME	PB	102	102	10	45	47	11	44	47	ARMS-PCR	0.88	7
Mizuki-1	2010	Japan	EA	HB	611	737	935^c	287^d		979^c	495^d		GeneChip	NA	5
Mizuki-2	2010	Korea	EA	HB	119	140	184^c	54^d		194^c	86^d		GeneChip	NA	4
Mizuki-3	2010	Turkey	ME	HB	1215	1279	931^c	1499^d		801^c	1757^d		GeneChip	NA	5
Shahram	2011	Iran	ME	HB	147	140	12	64	71	12	57	71	PCR-SSP	0.91	6
Khaib	2013	Algeria	Europe	PB	51	96	11	23	17	5	41	50	Direct sequencing	0.35	7
Wu	2014	China	EA	PB	407	679	209	167	31	302	295	82	Sequenom MassArray	0.45	9
Talaat	2014	Egypt	ME	HB	87	97	10	35	42	6	41	50	MS-PCR	0.53	6
Carapito	2015	Iran	ME	HB	552	341	376^c	728^d		255^c	579^d		Taqman	NA	5
Hu-1	2015	China	EA	PB	300	350	168	126	6	146	160	44	PCR-RFLP	0.99	10
Hu-2	2015	China	EA	PB	418	1403	216	175	27	558	679	166	PCR-RFLP	0.06	10
Al-Okaily	2015	Saudi Arabia	ME	PB	61	211	12	22	27	21	102	88	ARMS-PCR	0.27	8
Yu	2017	China	EA	PB	1206	2475	661	459	86	1121	1078	276	Real-time PCR	0.49	9
							-592A>C (rs1800872)
							AA	AC	CC	AA	AC	CC
Dilek	2009	Turkey	ME	PB	96	124	7	50	39	13	47	64	PCR-SSP	0.33	8
Ates	2010	Turkey	ME	PB	102	102	10	45	47	11	44	47	ARMS-PCR	0.88	7
Mizuki-1	2010	Japan	EA	HB	611	737	935^e	287^f		979^e	495^f		GeneChip	NA	5
Mizuki-2	2010	Korea	EA	HB	119	140	184^e	54^f		194^e	86^f		GeneChip	NA	4
Mizuki-3	2010	Turkey	ME	HB	1215	1279	931^e	1499^f		801^e	1757^f		GeneChip	NA	5
Shahram	2011	Iran	ME	HB	147	140	12	66	69	12	57	71	PCR-SSP	0.91	6
Khaib	2013	Algeria	Europe	PB	51	96	11	23	17	5	41	50	Direct sequencing	0.35	7
Montes-Cano	2013	Spain	Europe	PB	304	313	172^e	408^f		157^e	463^f		PCR-SSOP	NA	6
Hu-1	2015	China	EA	PB	300	350	170	120	10	140	174	36	PCR-RFLP	0.09	10
Al-Okaily	2015	Saudi Arabia	ME	PB	61	211	12	22	27	21	102	88	ARMS-PCR	0.27	8
Afkari	2018	Iran	ME	HB	46	61	24	20	2	16	41	4	PCR-RFLP	<0.01	5

HWE in control. PB: hospital-based control; HB: healthy-based control/normal control; a: A allele; b: G allele; c: T allele; d: C allele; e: A allele; f: C allele; EA: East Asian; ME: Middle East.