Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

Table 3

Summary ORs and 95% CI of IL-10 gene polymorphisms and Behcet’s disease risk.

Locus	N	OR	95% CI		(%)^a	OR	95% CI		(%)^a	OR	95% CI		(%)^a	OR	95% CI		(%)^a	OR	95% CI		(%)^a
-1082A>G (rs1800870)		G vs. A				AG vs. AA				GG vs. AA				AG+GG vs. AA				GG vs. AA+AG
Total	9	0.95	0.79-1.15	0.60	46.1	0.91	0.65-1.29	0.60	64.2	0.89	0.64-1.24	0.50	29.2	0.91	0.67-1.23	0.53	58.1	0.99	0.59-1.66	0.50	59.9
HWE—yes	4	1.04	0.72-1.54	0.83	69.1	0.87	0.65-1.17	0.99	81.9	1.45	0.83-2.51	0.19	0	1.05	0.58-1.92	0.87	79.0	1.30	0.61-2.77	0.59	41.6
HWE—no	4	0.85	0.70-1.03	0.09	0	0.99	0.51-1.94	0.36	0	0.68	0.44-1.03	0.07	15.8	0.81	0.61-1.07	0.13	0	0.83	0.42-1.63	0.95	66.4
Ethnicity
Europe	1	0.72	0.48-1.09	0.12	NA	0.67	0.35-1.29	0.23	NA	0.59	0.28-1.27	0.18	NA	0.64	0.36-1.15	0.14	NA	0.73	0.36-1.45	0.37	NA
ME	7	1.05	0.90-1.22	0.55	7.5	1.05	0.71-1.55	0.79	61.1	1.00	0.69-1.45	1.00	38.3	1.06	0.77-1.45	0.72	46.3	1.07	0.57-2.04	0.83	69.0
EA	1	0.56	0.35-0.89	0.01	NA	0.56	0.35-0.90	0.02	NA	0.36	0.01-8.88	0.53	NA	0.55	0.34-0.89	0.01	NA	0.39	0.02-9.55	0.56	NA
Design
HB	5	0.89	0.74-1.07	0.21	4.0	0.87	0.65-1.17	0.36	0	0.74	0.43-1.28	0.28	42.9	0.84	0.64-1.09	0.19	0	0.83	0.42-1.63	0.59	67.7
PB	4	1.02	0.70-1.47	0.93	68.3	0.98	0.49-1.95	0.96	82.1	1.37	0.76-2.46	0.30	0	1.01	0.53-1.90	0.98	80	1.30	0.59-2.86	0.52	43.2
-819T>C (rs1800871)		C vs. T				TC vs. TT				CC vs. TT				TC+CC vs. TT				CC vs. TT+TC
Total	16	0.72	0.68-0.76	<0.01	38.6	0.73	0.66-0.80	<0.01	23.0	0.52	0.39-0.70	<0.01	53.7	0.67	0.61-0.71	<0.01	22.1	0.66	0.53-0.82	<0.01	57.8
Ethnicity
Europe	2	0.67	0.33-1.36	0.27	78.6	0.46	0.16-1.37	0.17	49.3	0.36	0.07-1.83	0.22	77.0	0.41	0.11-1.58	0.20	70.1	0.70	0.33-1.47	0.35	65.0
ME	8	0.79	0.72-0.86	<0.01	0	0.92	0.55-1.52	0.74	40.8	0.78	0.53-1.14	0.20	0	0.84	0.59-1.21	0.36	7.4	0.81	0.65-1.01	0.06	5.2
EA	6	0.68	0.63-0.73	<0.01	34.1	0.72	0.65-0.80	<0.01	0	0.40	0.26-0.62	<0.01	72.6	0.67	0.60-.74	<0.01	0	0.47	0.32-0.71	<0.01	71.1
Design
HB	8	0.74	0.68-0.79	<0.01	36.7	0.92	0.56-1.49	0.73	0	0.74	0.46-1.20	0.23	0	0.83	0.52-1.21	0.42	0	0.81	0.62-1.04	0.10	10.7
PB	8	0.71	0.63-0.80	<0.01	45.7	0.72	0.65-0.80	<0.01	39.0	0.46	0.32-0.67	<0.01	65.4	0.66	0.56-0.78	<0.01	42.3	0.59	0.44-0.80	<0.01	64.1
Genotyping
PCR	9	0.76	0.66-0.89	<0.01	42.3	0.72	0.61-0.84	<0.01	22.8	0.57	0.37-0.89	0.01	59.8	0.64	0.55-0.75	<0.01	3.8	0.69	0.50-0.94	0.02	66.6
Other	7	0.71	0.65-0.78	<0.01	43.2	0.73	0.57-0.92	0.01	47.9	0.47	0.32-0.71	<0.01	50.2	0.67	0.50-0.88	<0.01	62.2	0.59	0.48-0.73	<0.01	0
-592A>C (rs1800872)		C vs. A				AC vs. AA				CC vs. AA				AC+CC vs. AA				CC vs. AA+AC
Total	11	0.71	0.63-0.80	<0.01	45.4	0.64	0.40-1.02	0.06	59.2	0.52	0.28-0.95	0.03	61.9	0.59	0.38-0.92	0.02	57.1	0.70	0.50-0.97	0.04	48.0
HWE—yes	6	0.75	0.58-0.96	0.02	60.9	0.71	0.43-1.19	0.20	59.6	0.54	0.28-1.04	0.07	67.8	0.65	0.40-1.06	0.08	59.0	0.69	0.48-1.00	0.05	56.6
HWE—no	1	0.53	0.29-0.95	0.03	NA	0.33	0.14-0.74	0.01	NA	0.33	0.05-2.04	0.24	NA	0.33	0.14-0.73	0.01	NA	0.65	0.11-3.70	0.63	NA
Ethnicity
Europe	2	0.63	0.37-1.09	0.10	73.7	0.25	0.08-0.82	0.02	NA	0.15	0.05-0.51	<0.01	NA	0.20	0.07-0.61	0.01	NA	0.46	0.23-0.93	0.03	NA
ME	6	0.77	0.69-0.85	<0.01	7.6	0.77	0.39-1.53	0.45	65.7	0.82	0.53-1.27	0.37	0	0.74	0.42-1.30	0.30	55.3	0.87	0.64-1.13	0.29	0
EA	3	0.60	0.53-0.68	<0.01	0	0.57	0.41-0.78	<0.01	NA	0.23	0.11-0.48	<0.01	NA	0.51	0.37-0.70	<0.01	NA	0.30	0.15-0.62	<0.01	NA
Design
HB	5	0.70	0.64-0.76	<0.01	39.1	0.61	0.18-2.11	0.43	76.6	0.79	0.36-1.71	0.55	8.4	0.58	0.18-1.85	0.36	74.4	0.84	0.54-1.32	0.45	0
PB	6	0.73	0.59-0.91	0.01	57.2	0.65	0.37-1.16	0.14	61.6	0.48	0.23-1.01	0.05	69.7	0.60	0.35-1.02	0.06	60.3	0.65	0.42-1.02	0.06	63.2
Genotyping
PCR	7	0.77	0.64-0.93	0.01	46.1	0.70	0.43-1.14	0.16	60.2	0.62	0.34-1.11	0.11	56.2	0.66	0.43-1.01	0.05	53.1	0.74	0.52-1.06	0.10	48.6
Other	4	0.65	0.56-0.76	<0.01	47.4	0.25	0.08-0.82	0.02	NA	0.15	0.05-0.51	<0.01	NA	0.20	0.07-0.61	0.01	NA	0.46	0.23-0.93	0.03	NA

Numbers of comparisons. ^aTest for heterogeneity. ME: Middle East; EA: East Asia; PB: population based; HB: healthy-based control/normal control.