Research Article
Elevated IL-12, TNF-α, and TNF-α/IL-10 Ratios in Stored Plasmodium falciparum-Infected Whole Blood: Implications for Safe Haemotransfusion
Table 2
Amounts of cytokines released into an average of 500 mL of stored whole blood.
| | Mean levels per 500 mL infected donor blood | | Cytokines | Day 0 | Day 7 | Day 14 | Day 21 | Day 28 | Day 35 |
| | Malaria-infected donor blood | | IL-10 (ng) | 25.5 | 14.0 | 10.5 | 1.1 | 0.0 | 0.0 | | IL-6 (ng) | 35.5 | 130 | 170.0 | 190.0 | 100.0 | 13.5 | | TNF-α (ng) | 16.9 | 49.3 | 65.6 | 71.6 | 75.1 | 90.2 | | IL-12 (ng) | 14.2 | 27.5 | 36.6 | 48.2 | 55.4 | 73.7 | | Malaria-noninfected donor blood (control) | | IL-10 (ng) | 9.5 | 5.5 | 3.5 | 2.6 | 1.7 | 0.9 | | IL-6 (ng) | 15.4 | 9.7 | 10.8 | 11.4 | 13.7 | 15.6 | | TNF-α (ng) | 11.4 | 13.4 | 15.0 | 21.3 | 29.4 | 32.4 | | IL-12 (ng) | 8.1 | 9.18 | 15.8 | 31.7 | 16.2 | 11.1 |
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Abbreviations: ng: nanogram (10 -9 gram); Dunn’s post hoc test indicated significant levels from mean day 0 levels. |
