Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping

Figure 5

Schematic illustrations of SARS-Cov-2 S protein. (a) Locations of IgY-S epitopes in SARS-Cov-2 S. Locations of the five identified IgY-S epitopes are indicated by arrows. SS: signal sequence; NTD: N-terminal domain; RBD: receptor-binding domain; SD1: subdomain 1; SD2: subdomain 2; S1/S2: S1/S2 cleavage region; S2: S2 cleavage region; FP: fusion peptide; HR1: heptad repeat 1; CH: central helix; CD: connector domain; HR2: heptad repeat 2. (b) 3D view of SARS-CoV-2 S trimer based on PDB 6VXX [37], constructed by UCSF Chimera. The S1/S2 cleavage site is indicated by an arrowhead. The yellow strand represents a peptide containing epitope SIIAYTMSL.

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