Knockdown of YAP/TAZ Inhibits the Migration and Invasion of Fibroblast Synovial Cells in Rheumatoid Arthritis by Regulating Autophagy

Figure 6

YAP or TAZ knockdown reduced the migratory and invasive ability of RA-FLS through autophagy induction. (a, b) Migration and invasion of stable YAP or TAZ knockdown RA-FLS and their corresponding control cells in the presence or absence of 10 mM 3-MA or 30 μM CQ were determined by Transwell assays. Representative images of three independent experiments are shown. Magnification, ×200. (c, d) Quantification of relative numbers of migrated and invaded cells in five random fields for each replicate was shown. All experiments were performed independently three times, and data were shown as . relative to shYAP or shTAZ in the absence of 3-MA and CQ by Student’s -test.

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