Dendritic Cells Transfected with MHC Antigenic Determinants of CBA Mice Induce Antigen-Specific Tolerance in C57Bl/6 Mice

Figure 2

Relative quantities of cells expressing surface markers (a) CD80⁺, (b) CD86⁺, (c) CD83⁺, and (d) CD40⁺ among groups of electroporated and nonelectroporated DCs. per group. Data are presented as median and interquartile range. Brackets indicate significant differences (Kruskal-Wallis test with Dunn’s corrected multiple comparisons, , , ). Non-EP DC: nonelectroporated DCs; EP DC: DCs electroporated without a plasmid; DCp5: DCs electroporated with a control plasmid encoding antigenic determinants from the H2 locus of CBA mice, which do not differ from the homologous antigenic determinants of C57BL/6 mice; DCpIL-10: DCs electroporated with a plasmid encoding mouse IL-10; DCpMHC: DCs electroporated with a plasmid encoding antigenic determinants from the H2 locus of CBA mice, which differ from the homologous antigenic determinants of C57BL/6 mice.

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