Review Article
The Emerging Roles of Tripartite Motif Proteins (TRIMs) in Acute Lung Injury
Table 1
Role of TRIMs in acute lung inflammation.
| TRIMs | Models | Cell types | Mechanisms | Ref No. |
| TRIM8 | LPS-induced AHI | Human liver cells | LINC00472/miR-373-3p/TRIM8 axis | [51] | LPS-induced ALI | Lung epithelial cells | p-AMPKα/NF-κB/Nrf2/ROS/HO-1 axis | [52] | TRIM14 | LPS-induced ALI | Human vascular endothelial cells | NEMO/TAK1/NF-κb/TRIM14 pathway | [63] | TRIM21 | LPS-induced ALI | Lung microvascular endothelial cells | NF-κB signaling | [79] | TRIM65 | ALI | Human vascular endothelial cells | VACM-1 ubiquitination and degradation | [45] | TRIM72 | Ischaemia-reperfusion and overventilation-induced ALI | Lung epithelial cells | Cell membrane repair | [97] | Influenza virus -induced ALI | Macrophage Lung tissue | NF-κB signaling Inhibition of pyroptosis | [98, 106] | Hemorrhagic shock/contusive ALI | Human bronchial epithelial cells | Cell membrane repair | [46] |
|
|