The Emerging Roles of Tripartite Motif Proteins (TRIMs) in Acute Lung Injury

Table 1

Role of TRIMs in acute lung inflammation.

TRIMs	Models	Cell types	Mechanisms	Ref No.
TRIM8	LPS-induced AHI	Human liver cells	LINC00472/miR-373-3p/TRIM8 axis	[51]
	LPS-induced ALI	Lung epithelial cells	p-AMPKα/NF-κB/Nrf2/ROS/HO-1 axis	[52]
TRIM14	LPS-induced ALI	Human vascular endothelial cells	NEMO/TAK1/NF-κb/TRIM14 pathway	[63]
TRIM21	LPS-induced ALI	Lung microvascular endothelial cells	NF-κB signaling	[79]
TRIM65	ALI	Human vascular endothelial cells	VACM-1 ubiquitination and degradation	[45]
TRIM72	Ischaemia-reperfusion and overventilation-induced ALI	Lung epithelial cells	Cell membrane repair	[97]
	Influenza virus -induced ALI	Macrophage; Lung tissue	NF-κB signaling; Inhibition of pyroptosis	[98, 106]
	Hemorrhagic shock/contusive ALI	Human bronchial epithelial cells	Cell membrane repair	[46]